Inability of oxytocin to activate pyruvate dehydrogenase in the Brattleboro rat

See allHide authors and affiliations

Science  28 May 1982:
Vol. 216, Issue 4549, pp. 1010-1012
DOI: 10.1126/science.7079746


Oxytocin has insulin-like activity in that it stimulates lipogenesis and increases pyruvate dehydrogenase activity. However, in adipocytes from homozygous Brattleboro rats oxytocin is incapable of stimulating lipogenesis or pyruvate dehydrogenase activity, although insulin stimulation of both processes is normal and the antilipolytic activity of oxytocin is normal. Thus, the Brattleboro rat provides a new genetic model for the study of oxytocin action, wherein recognition of the chemical mediator is partially defective.