Reports

Spherical Crystallization: Direct Spherical Agglomeration of Salicylic Acid Crystals During Crystallization

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Science  04 Jun 1982:
Vol. 216, Issue 4550, pp. 1127-1128
DOI: 10.1126/science.216.4550.1127

Abstract

Direct spherical agglomeration of salicylic acid crystals during crystallization is described. The needle-like salicylic acid crystals simultaneously form and agglomerate in a mixture of three partially miscible liquids, such as water, ethanol, and chloroform, with agitation. The agglomerates can be made directly into tablets because of their excellent flowability. Spherical crystallization could eliminate the usual separate agglomeration step after crystallization and may be adaptable to other pharmaceutical and chemical systems.