Reports

HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression

+ See all authors and affiliations

Science  11 Jun 1982:
Vol. 216, Issue 4551, pp. 1233-1235
DOI: 10.1126/science.6177045

Abstract

A new human erythroleukemia cell line has been established. This line, designated HEL, is capable of spontaneous and induced globin synthesis, producing mainly G gamma and A gamma chains. Embryonic chains (epsilon, zeta) and alpha chains are detectable in very small amounts; beta chains are undetectable. This line provides a new model system for studying aspects of erythroid cell differentiation and differential globin gene expression.