Tritiated imipramine binding sites are decreased in the frontal cortex of suicides

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Science  18 Jun 1982:
Vol. 216, Issue 4552, pp. 1337-1339
DOI: 10.1126/science.7079769


Binding characteristics of tritiated imipramine were determined in the frontal cortex of suicides and well-matched controls. Maximal binding was significantly lower in brains from the suicides. This finding is consistent with reports of decreased tritiated imipramine binding in the platelets of patients diagnosed as having a major affective disorder.