Schizophrenia: dopamine beta-hydroxylase activity and treatment response

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Science  25 Jun 1982:
Vol. 216, Issue 4553, pp. 1423-1425
DOI: 10.1126/science.6124036


Cerebrospinal fluid levels of dopamine beta-hydroxylase, found to be relatively constant over time in individual patients, were significantly lower in schizophrenic patients who became nonpsychotic during neuroleptic treatment than in those who remained psychotic. Dopamine beta-hydroxylase activity may delineate a subgroup of patients who have a dopamine-sensitive brain disorder.