Differential breakdown of phylogenetically diverse ribosomal RNA's inserted via liposomes into mammalian cells

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Science  02 Jul 1982:
Vol. 217, Issue 4554, pp. 59-61
DOI: 10.1126/science.6178157


Liposomes were used to deliver ribosomal RNA's from the different organisms into cultivated mouse plasmacytoma cells. Ribosomal RNA from Escherichia coli was degraded intracellularly within 1 hour, whereas mouse and yeast ribosomal RNA's were degraded more slowly. This indicates that cells can discriminated between different ribosomal RNA's.