Rat pro-opiomelanocortin contains sulfate

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Science  02 Jul 1982:
Vol. 217, Issue 4554, pp. 63-64
DOI: 10.1126/science.6283633


Intermediate lobes isolated from rat pituitary glands incorporated [35S]sulfate into pro-opiomelanocortin and other adrenocorticotropic hormone-containing peptides. Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller products. Pro-opiomelanocortin that accumulated in the presence of canavanine was also sulfated.