Transcriptional control signals of a eukaryotic protein-coding gene

Science  23 Jul 1982:
Vol. 217, Issue 4557, pp. 316-324
DOI: 10.1126/science.6283634


Transcriptional control signals of a model eukaryotic protein-coding gene have been identified by a new procedure of in vitro mutagenesis. This method allows small clusters of nucleotide residues to be substituted in a site-directed manner without causing the addition or deletion of other sequences. Transcription assays of a systematic series of these clustered point mutants have led to the identification of three distinct control signals located within the 105-nucleotide residues immediately upstream from the point where transcription begins.

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