Lethal effect of phenothiazine neuroleptics on the pathogenic protozoan Leishmania donovani

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Science  23 Jul 1982:
Vol. 217, Issue 4557, pp. 369-371
DOI: 10.1126/science.6124040


Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and antiemetic effects, have been found to have protozoacidal effects on the human pathogen Leishmania donovani. These compounds are lethal to both the extracellular stage of the organism, which is inoculated into humans by the sand fly, and the intracellular stage, which is found solely in human macrophages during established infection.