Genetic length of a human chromosomal segment measured by recombination between two fragile sites

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Science  23 Jul 1982:
Vol. 217, Issue 4557, pp. 373-374
DOI: 10.1126/science.7089572


Two families were studied in which the same homolog of chromosome pair 10 expressed both the fragile sites on the long (q) arm at 10q23 and 10q25. Recombination between the fragile sites was observed in 3 of the 27 offspring in whom it could occur. The genetic length of chromosome between the fragile sites was 11 female centimorgans within a 95 percent probability interval of 4 to 28 centimorgans. This estimate of genetic length is comparable to those obtained with other methods.