Diverse mechanisms in the generation of human beta-tubulin pseudogenes

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Science  06 Aug 1982:
Vol. 217, Issue 4559, pp. 549-552
DOI: 10.1126/science.6178164


The sequence of two human beta-tubulin pseudogenes is described. One contains an intervening sequence but lacks sequences encoding the 55 N-terminal amino acids of the polypeptide chain. A second has no introns but has a polyadenylate signal and an oligoadenylate tract at its 3' end, and it is flanked by a short direct repeat. These sequences have arisen by different mechanisms, including one that probably involves reverse transcription of a processed messenger RNA and reintegration of the complementary DNA copy into the genome.