Adrenal medullary enkephalin-like peptides may mediate opioid stress analgesia

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Science  06 Aug 1982:
Vol. 217, Issue 4559, pp. 557-559
DOI: 10.1126/science.7089582


Different patterns of fact shock activate opioid and nonopioid mechanisms of stress analgesia in the rat. Opioid, but not nonopioid, stress analgesia is reduced by adrenal demedullation and denervation and is potentiated by reserpine, a drug known to increase concentrations of adrenal medullary enkephalin-like peptides. It is suggested that adrenal enkephalins mediate opioid stress analgesia.