Cigarette smoke contains anticoagulants against fibrin aggregation and factor XIIIa in plasma

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Science  13 Aug 1982:
Vol. 217, Issue 4560, pp. 642-645
DOI: 10.1126/science.6124042


Gas-phase, water-soluble components of cigarette smoke cause delayed fibrin self-assembly and prevent fibrin cross-linking by inactivation of factor XIIIa (plasma transglutaminase). These anticoagulant properties of smoke are demonstrable in plasma, suggesting they play a role in the pathophysiology of smoking.