Reports

Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells

+ See all authors and affiliations

Science  03 Sep 1982:
Vol. 217, Issue 4563, pp. 939-941
DOI: 10.1126/science.7112106

Abstract

Cytogenic studies were performed on the direct chromosome preparations of the renal cell carcinoma cells and the cultured peripheral blood lymphocytes of a patient with familial renal cell carcinoma. The results revealed a specific, acquired translocations (3p;11p) present in the majority of metaphases of the tumor, indicating that the development of renal cell carcinoma is associated with a deletion in the proximal end of 3p. Renal cell carcinoma is thus the third example--the first two being retinoblastoma and Wilms' tumor--of a chromosomal deletion occurring germinally or somatically in association with a specific tumor. This finding adds further support to the existence of specific human cancer genes.

Related Content