Polyamine depletion influences drug-induced chromosomal damage

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Science  10 Sep 1982:
Vol. 217, Issue 4564, pp. 1044-1046
DOI: 10.1126/science.6810463


Polyamines have been implicated in the intracellular stabilization of DNA. Depletion of intracellular polyamines influences the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum II. By means of the sister chromatid exchange assay, it was found that intracellular polyamine depletion can also alter the induction of chromosomal damage by these cytotoxic agents.