Reports

Polyamine depletion influences drug-induced chromosomal damage

+ See all authors and affiliations

Science  10 Sep 1982:
Vol. 217, Issue 4564, pp. 1044-1046
DOI: 10.1126/science.6810463

Abstract

Polyamines have been implicated in the intracellular stabilization of DNA. Depletion of intracellular polyamines influences the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum II. By means of the sister chromatid exchange assay, it was found that intracellular polyamine depletion can also alter the induction of chromosomal damage by these cytotoxic agents.

Related Content