Plasmodium falciparum gametocytes from culture in vitro develop to sporozoites that are infectious to primates

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Science  10 Sep 1982:
Vol. 217, Issue 4564, pp. 1048-1050
DOI: 10.1126/science.7051285


Gametocytes of two strains of the human malaria parasite Plasmodium falciparum have been produced in high density by means of a continuous-flow cultivation system. The gametocytes of these two strains infected a mean of 36 percent and 71 percent, respectively, of Anopheles freeborni mosquitoes that fed on a suspension of red blood cells containing the culture gametocytes. Sporozoites harvested from the infected mosquito salivary glands were infective to the chimpanzee (Pan troglodytes) and the owl monkey (Aotus trivirgatus).