Stereoselective antagonism of phencyclidine's discriminative properties by adenosine receptor agonists

Science  17 Sep 1982:
Vol. 217, Issue 4565, pp. 1157-1159
DOI: 10.1126/science.6287578


Rats trained to discriminate between phencyclidine and saline vehicle were used to test various agents for their ability to mimic or block the phencyclidine cue. ketamine, dexoxadrol, tiletamine, and phencyclidine analogs were found to mimic phencyclidine's behavioral effects. Treatment with the adenosime receptor agonists N6-cyclohexyladenosine and L-phenylisopropyladenosine blocked the discriminative properties of phencyclidine. These results suggest that adenosine receptor agonists might be useful in treating phencyclidine-induced psychosis.