Are ions involved in the gating of calcium channels?

Science  08 Oct 1982:
Vol. 218, Issue 4568, pp. 153-156
DOI: 10.1126/science.6289432


The rates of activation and deactivation of the currents carried by calcium, strontium, or barium ions through the voltage-sensitive calcium channel of Paramecium are different. The differences cannot be attributed to complications due to internal ion concentration, calcium channel inactivation, potassium current activation, surface charge effects, or incomplete space clamping. The findings indicate participation of the divalent cations in the voltage-driven calcium channel gating process.