Bilirubin-induced modulation of cerebral protein phosphorylation in neonate rabbits in vivo

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Science  08 Oct 1982:
Vol. 218, Issue 4568, pp. 156-158
DOI: 10.1126/science.7123226


Protein phosphorylation in cerebral cell-free preparations from neonate rabbits was inhibited by bilirubin and promoted by aminophylline when these substances had been administered intravenously. In animals given both compounds, the bilirubin-induced inhibition of phosphorylation was partly reversed by aminophylline. Adenosine 3',5'-monophosphate added in vitro during the assays also increased protein phosphorylation. These data introduce new concepts in the pathogenesis of kernicterus.