Nonimmunological production of leukotrienes induced by platelet-activating factor

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Science  15 Oct 1982:
Vol. 218, Issue 4569, pp. 286-289
DOI: 10.1126/science.7123233


Platelet-activating factor caused rapid pulmonary vasoconstriction and edema in isolated lungs perfused with albumin-free salt solution devoid of formed blood elements. These effects may be due in part to the action of leukotrienes D4 and C4, which were identified by bioassay and high-pressure liquid chromatography in the lung effluent after stimulation by platelet-activating factor. These findings help illuminate some of the deleterious effects that platelet-activating factor elicits in anaphylactic reactions and possibly in other forms of lung injury.