Hemoglobin Parchman: double crossover within a single human gene

See allHide authors and affiliations

Science  15 Oct 1982:
Vol. 218, Issue 4569, pp. 291-293
DOI: 10.1126/science.7123235


Structural analysis of a new variant hemoglobin revealed tryptic peptides with the amino acid composition of normal delta-globin, except for two internal peptides, which had the compositions of normal beta-globin. The most likely explanation for these findings is that a double, nonhomologous crossover between the delta-and beta-globin genes had occurred.