Angiogenesis induced by "normal" human breast tissue: a probable marker for precancer

Science  15 Oct 1982:
Vol. 218, Issue 4569, pp. 293-295
DOI: 10.1126/science.6181563


Normal human breast lobules, freshly isolated by precision microdissection of tissue stained with methylene blue chloride, were assayed for their ability to induce neovascularization (angiogenesis) in rabbit irises. Histologically, normal lobules from cancerous breast induced angiogenesis twice as often as lobules from noncancerous breasts, suggesting that preneoplastic transformation is diffuse.