Prenatal and neonatal exposure to cimetidine results in gonadal and sexual dysfunction in adult males

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Science  29 Oct 1982:
Vol. 218, Issue 4571, pp. 493-494
DOI: 10.1126/science.7123252


Exposure of rats to cimetidine during intrauterine life and the immediate neonatal period results in hypoandrogenization in adult life with decreased weights of androgen-dependent tissues and decreased concentrations of testosterone. Moreover, sexual behavior patterns in adult life are disturbed as shown by a lack of sexual motivation and decreased performance.