Damage to hypothalamic dopaminergic neurons is associated with development of prolactin-secreting pituitary tumors

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Science  12 Nov 1982:
Vol. 218, Issue 4573, pp. 684-686
DOI: 10.1126/science.7134966


Old female rats with spontaneous prolactin-secreting pituitary tumors (prolactinomas) and young females with prolactinomas produced by prolonged estrogen treatment had damaged tuberoinfundibular dopaminergic neurons. Since these neurons inhibit the function of pituitary prolactin-secreting cells, their destruction may lead to development of prolactinomas.