Cotransmitters in the motor nerves of the guinea pig vas deferens: electrophysiological evidence

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Science  12 Nov 1982:
Vol. 218, Issue 4573, pp. 693-695
DOI: 10.1126/science.6291151


The contractile response of the guinea pig vas deferens to motor nerve stimulation is biphasic. The first phase is antagonized by the specific adenosine triphosphate-receptor antagonist arylazido aminoproprionyl adenosine triphosphate (ANAPP3), and the second by the alpha-receptor antagonist prazosin. The underlying electrical event, the excitatory junction potential, is also blocked by ANAPP3, but not by prazosin.