Maternal ethanol exposure induces transient impairment of umbilical circulation and fetal hypoxia in monkeys

Science  12 Nov 1982:
Vol. 218, Issue 4573, pp. 700-702
DOI: 10.1126/science.6890235

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When ethanol was administered intravenously to pregnant monkeys, a transient but marked collapse of umbilical vasculature was observed uniformly within about 15 minutes. The ethanol-induced impairment of umbilical circulation produced severe hypoxia and acidosis in the fetus; recovery occurred during the succeeding hour. This striking interruption of feto-placental circulation may explain one of the mechanisms of mental retardation, a frequent manifestation in children afflicted with fetal alcohol syndrome.