Chromosomal assignment of the endogenous proto-oncogene C-abl

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Science  24 Dec 1982:
Vol. 218, Issue 4579, pp. 1317-1319
DOI: 10.1126/science.6293057


Abelson murine leukemia virus (A-MuLV) is a replication-defective retrovirus that transforms lymphocytes of the B-cell lineage. This virus is a recombinant between the parental Moloney murine leukemia virus and a cellular gene termed C-abl. By analysis of a series of mouse x Chinese hamster hybrid celllines containing various mouse chromosomes, we have mapped the C-abl gene to mouse chromosome 2.