Reports

Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas

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Science  24 Dec 1982:
Vol. 218, Issue 4579, pp. 1319-1321
DOI: 10.1126/science.7146913

Abstract

Hybridization studies with viral oncogene probes indicate that c-myc, the cellular gene homologous to the transforming gene of avian myelocytomatosis virus, resides on mouse chromosome 15 and in many plasmacytomas is translocated to the antibody heavy chain gene locus on chromosome 12. The transcriptional orientation of the translocated c-myc sequence is opposite the orientation of the adjacent C alpha gene that codes for the heavy chain of immunoglobulin A. The translocated c-myc sequence is not the same oncogene detected in urine plasmacytomas by the NIH-3T3 cell transformation assay.