Guanosine triphosphate activation of brain adenylate cyclase: enhancement by long-term antidepressant treatment

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Science  07 Jan 1983:
Vol. 219, Issue 4580, pp. 65-67
DOI: 10.1126/science.6849117


Activation of adenylate cyclase by a stable guanosine 5'-triphosphate analog was augmented in brain membrane preparations from rats treated on a long-term basis with tricyclic antidepressants or electroconvulsive shock. These treatments may facilitate cyclase activation by promoting the interaction of the regulatory and catalytic subunits of the enzyme. This finding suggests a possible mechanism for the changes in sensitivity to various neurotransmitters seen after antidepressant administration.