Parathyroid hormone: effects of the 3-34 fragment in vivo and vitro

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Science  07 Jan 1983:
Vol. 219, Issue 4580, pp. 67-69
DOI: 10.1126/science.6849118


The biologically active fragment ofparathyroid hormone, consisting of residues 1-34, and its in vitro antagonist, fragment 3-34, were administered separately or in combination to chronically thyroparathyroidectomized dogs. These fragments were also studied in vitro with dog renal cortical membranes. Fragment 3-34 inhibited the stimulation of adenylate cyclase by fragment 1-34 in vitro, but had no agonist or antagonistic effects on renal phosphate transport in vivo.