Prostaglandins mediate inhibition of gastric acid secretion by somatostatin in the rat

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Science  21 Jan 1983:
Vol. 219, Issue 4582, pp. 301-303
DOI: 10.1126/science.6129701


Somatostatin, a tetradecapeptide with potent inhibitory actions on gastric acid secretion, potentiated carbamylcholine-induced synthesis and release of prostaglandin E2 from isolated perfused rat stomachs. The ability of somatostatin to inhibit acid secretion was blocked by indomethacin, an inhibitor of prostaglandin synthesis. These results suggest that prostaglandins mediate gastric acid inhibition by somatostatin in the rat.