A bean alpha-amylase inhibitor formulation (starch blocker) is ineffective in man

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Science  28 Jan 1983:
Vol. 219, Issue 4583, pp. 393-395
DOI: 10.1126/science.6184780


A commercial alpha-amylase inhibitor with potent inhibitory activity in vitro was used in a randomized double-blind, cross-over clinical trial in six nonobese, healthy adult males. In these subjects, this inhibitor had no effect on the response of blood glucose, insulin, or breath hydrogen to a standardized starch meal. It is concluded that this formulation has no effect on starch digestion in humans.