Nigral transplants reinnervating the dopamine-depleted neostriatum can sustain intracranial self-stimulation

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Science  28 Jan 1983:
Vol. 219, Issue 4583, pp. 416-419
DOI: 10.1126/science.6849143


Transplants of embryonic substantia nigra reinnervated the striatum and were able to sustain intracranial self-stimulation in rats with brain lesions induced by 6-hydroxydopamine. Dopaminergic drugs and alterations in current intensity produced typical changes in response rates. Animals with electrodes implanted into cortical grafts or into the denervated striatum failed to exhibit self-stimulation. These findings suggest that transplanted dopamine neurons convey specific, temporally organized information axonally to the striatum.