Protein engineering

Science  11 Feb 1983:
Vol. 219, Issue 4585, pp. 666-671
DOI: 10.1126/science.6572017


The prospects for protein engineering, including the roles of x-ray crystallography, chemical synthesis of DNA, and computer modelling of protein structure and folding, are discussed. It is now possible to attempt to modify many different properties of proteins by combining information on crystal structure and protein chemistry with artificial gene synthesis. Such techniques offer the potential for altering protein structure and function in ways not possible by any other method.