Tumor suppression with a combination of alpha-difluoromethyl ornithine and interferon

Science  18 Feb 1983:
Vol. 219, Issue 4586, pp. 851-853
DOI: 10.1126/science.6186025


alpha-Difluoromethyl ornithine and mouse type 1 interferon, when administered simultaneously, were highly toxic to B16 melanoma cells in culture. Oral administration of alpha-difluoromethyl ornithine suppressed B16 melanoma development in mice 85 percent whereas interferon given subcutaneously inhibited tumor growth only 24 percent. Total or near total suppression of tumor growth was observed in mice receiving both treatments.