Intracellular calcium measurements with arsenazo III during cyclic AMP injections into molluscan neurons

See allHide authors and affiliations

Science  18 Feb 1983:
Vol. 219, Issue 4586, pp. 869-871
DOI: 10.1126/science.6297009


Injections of cyclic adenosine monophosphate into molluscan neurons often produce a transient membrane depolarization. By using the calcium indicator dye arsenazo III, it was found that cyclic nucleotide injections into neurons of Archidoris montereyensis resulted in elevation of internal calcium concentrations. However, this was demonstrated to be a secondary consequence of an induced increase in membrane sodium permeability, and not due to any direct effect of cyclic adenosine monophosphate on cellular calcium influx or internal calcium regulating processes.