Barbiturate-enhanced detection of brain lesions by carbon-14-labeled 2-deoxyglucose autoradiography

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Science  18 Feb 1983:
Vol. 219, Issue 4586, pp. 879-881
DOI: 10.1126/science.6823556


Cerebral glucose metabolism in rats was examined 1 week after the production by ibotenic acid of unilateral striatal lesions. The incorporation of carbon-14-labeled deoxyglucose decreased within the lesion but much less than that of carbon-14-labeled glucose. Barbiturate anesthesia caused a reversal of the asymmetric striatal deoxyglucose labeling, such that the lesioned striatum retained more tracer than the contralateral side. The combined use of barbiturates and radiolabeled deoxyglucose may enhance the identification of recent brain infarction in experimental animals and in man.