Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat

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Science  25 Feb 1983:
Vol. 219, Issue 4587, pp. 975-977
DOI: 10.1126/science.6823559


Weekly transfusions of whole blood from a nondiabetic subline of BB/W rats reduced the incidence of diabetes in susceptible BB/W rats from 39 to 0 percent and the incidence of pancreatic insulitis from 64 to 6 percent. Responsiveness of lymphocytes to concanavalin A was found to be low in rats with diabetes or insulitis. Transfusion restored concanavalin A responsiveness to levels observed in control rats free of diabetes or insulitis. These data suggest that whole blood alters the course of autoimmune BB/W rat diabetes.