Role of surface-active phospholipids in gastric cytoprotection

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Science  18 Mar 1983:
Vol. 219, Issue 4590, pp. 1327-1329
DOI: 10.1126/science.6828859


Intragastric administration of a liposomal surfactant suspension markedly reduced acid-induced gastric ulcerogenesis and bleeding in rats. The concentration of surface-active molecules intrinsically present in the gastric mucosa was increased two to six times by administration of 16,16-dimethyl prostaglandin E2. Thus, local accumulation of surface-active phospholipids may be an integral component of the cytoprotective mechanism activated by prostaglandin treatment.