Tunicamycin enhances the antiviral and anticellular activity of interferon

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Science  18 Mar 1983:
Vol. 219, Issue 4590, pp. 1339-1341
DOI: 10.1126/science.6187067


The inhibitory effects of interferon on virus multiplication and cell growth are significantly enhanced by treatment with tunicamycin. Potentiation of antiviral activity was found only with enveloped viruses and not with nonbudding viruses. Changes in the plasma membrane of treated cells may account for this effect, since enveloped viruses bud from the cell surface as a terminal step.