Activation of 2-aminofluorene by cultured plant cells

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Science  25 Mar 1983:
Vol. 219, Issue 4591, pp. 1427-1429
DOI: 10.1126/science.6338591


Cultured tobacco plant cells activated 2-aminofluorene to an agent mutagenic to Salmonella typhimurium strain TA98. The plant activation of 2-aminofluorene is heat-inactivated and may not involve solely cytochrome P-450. The kinetics of activation demonstrated both time- and concentration-dependent responses.