Salt-induced conversion of B-DNA to Z-DNA inhibited by aflatoxin B1

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Science  25 Mar 1983:
Vol. 219, Issue 4591, pp. 1434-1436
DOI: 10.1126/science.6402818


The carcinogen aflatoxin B1 was reacted with a polymer of alternating deoxyguanine and deoxycytosine residues to determine the effect that adduct formation has on the conversion of this polymer from the right-handed B-DNA form found at low salt concentrations to the left-handed Z-DNA form found at high salt concentrations. Reaction with aflatoxin strongly inhibited the salt-induced conversion of this polymer from B-DNA to Z-DNA. This inhibition could be detected even at relatively low binding levels.