Reports

Early morning insomnia with rapidly eliminated benzodiazepines

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Science  01 Apr 1983:
Vol. 220, Issue 4592, pp. 95-97
DOI: 10.1126/science.6131538

Abstract

Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short elimination half-lives, when tolerance had begun to develop. Early morning insomnia may be a variant of rebound insomnia and therefore specific to benzodiazepines, or it may occur with any rapidly eliminated sedative-hypnotic agent.