Total Synthesis of the L-Hexoses

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Science  27 May 1983:
Vol. 220, Issue 4600, pp. 949-951
DOI: 10.1126/science.220.4600.949


Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four steps. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.