Frequent activation of c-kis as a transforming gene in fibrosarcomas induced by methylcholanthrene

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Science  27 May 1983:
Vol. 220, Issue 4600, pp. 955-956
DOI: 10.1126/science.6302839


The DNA's from two of four methylcholanthrene-induced mouse fibrosarcomas contained transforming genes that were identical in their pattern of restriction endonuclease resistance to inactivation of biologic activity. This transforming gene was identified as the activated homolog of the Kirsten murine sarcoma virus onc gene, v-kis. The finding that a defined carcinogen reproducibly leads to activation of kis as a transforming gene should be of value in elucidating the role of oncogenes in the neoplastic process.