Reports

DNA methylation decreases in aging but not in immortal cells

Science  03 Jun 1983:
Vol. 220, Issue 4601, pp. 1055-1057
DOI: 10.1126/science.6844925

Abstract

When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.

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