Adrenocorticotropic hormone causes long-lasting potentiation of transmitter release from frog motor nerve terminals

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Science  03 Jun 1983:
Vol. 220, Issue 4601, pp. 1071-1072
DOI: 10.1126/science.6133353


Exposure of frog neuromuscular preparations to adrenocorticotropic hormone for several minutes increased both nerve-evoked and spontaneous transmitter release for several hours. No changes in postsynaptic sensitivity to transmitter were detected. The long-lasting potentiation shows little sensitivity to changes in extracellular calcium concentration and seems to be entirely presynaptic in origin.