Hemoglobin aggregation in single red blood cells of sickle cell anemia

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Science  10 Jun 1983:
Vol. 220, Issue 4602, pp. 1173-1175
DOI: 10.1126/science.6857241


A laser light scattering technique was used to observe the extent of hemoglobin aggregation in solitary red blood cells of sickle cell anemia. Hemoglobin aggregation was confirmed in deoxygenated cells. The light scattering technique can also be applied to cytoplasmic studies of any biological cell.