Clot-selective coronary thrombolysis with tissue-type plasminogen activator

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Science  10 Jun 1983:
Vol. 220, Issue 4602, pp. 1181-1183
DOI: 10.1126/science.6602378


Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.