Intermolecular interactions in collagen self-assembly as revealed by Fourier transform infrared spectroscopy

See allHide authors and affiliations

Science  17 Jun 1983:
Vol. 220, Issue 4603, pp. 1288-1290
DOI: 10.1126/science.6857249


When a solution of collagen molecules, at neutral pH and moderate ionic strength, is warmed from 4 degrees to 30 degrees C, a spontaneous self-assembly process takes place in which native-type collagen fibers are produced. Events occurring during thermally induced fibrillogenesis process can be monitored, in aqueous media and in real time, by Fourier transform infrared spectroscopic techniques. Tentative assignments of observed spectral bands are given.